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Title: Synthesis, DNA binding and equilibrium investigation of Model Pd(II)pip complexes with some selected DNA unit-constituents
Author(s): Hannen H. Elgedany, Azza A. Shoukry
Pages: 1-12 Paper ID:181606-3939-IJBAS-IJENS Published: December, 2018
Abstract: For the purpose of finding additional metal based anticancer medications with lower toxicity and higher affectivity, Pd(Pip)Cl2 complex, where Pip is piprazine, was synthesized and characterized. The stoichiometries and stability constants of the complexes formed between [Pd(Pip)(H2O)2]2+ and some selected bimolecular targets as DNA unit constituents were investigated at 25°C and at constant 0.1 mol.dm-3 ionic strength. The various complex species formed were evaluated utilizing concentration distribution diagrams. Solid ternary complexes involving [Pd(Pip)]2+ with inosine, guanosine and adenine have been synthesized and characterized , and tested for their biological activity against some selected bacteria and fungi. A further investigation of the binding properties of the diaqua complex [Pd(Pip)(H2O)2]2+ with calf thymus DNA (CT-DNA) was investigated by UV–Vis spectroscopy throughout this research. The intrinsic binding constants (Kb) calculated from UV– Vis absorption studies is 4.68x103 mol.dm-3. The calculated (Kb) value was found to be of lower magnitude than that of the classical intercalator EB (ethidium bromide) (Kb = 1.23 (±0.07) x 105 mol.dm-3), suggesting an electrostatic and/or groove binding mode for the interaction with CT-DNA.
Keywords: ---
Full Text (.pdf)  International Journals Of Engineering and Science | 892 KB
Title: Assessment of Heavy Metals Toxicity in Sediments at lake Edku, Egypt
Author(s): Mohamed A. Okbah, Maie I. El-Gammal, Mahmoud S. Ibrahim, Yousef A. A. Waheshi
Pages: 13-23 Paper ID:182706-3434-IJBAS-IJENS Published: December, 2018
Abstract: The study is carried out to assess the level contamination of some heavy metals content (Fe, Mn, Zn, Cu, Ni, Cr, Co and Pb) in the sediment of Lake Edku. To achieve that five indices for pollution assessment are used; toxic unit values (TU), Toxic risk index (TRI), Enrichment Factor (EF), Geoaccumulation Index (Igeo) and Pollution Load Index (PLI). The results of the total metals concentration are decreased in the order of Fe > Mn >Cr >Co >Zn > Cu >Ni= Pb. The calculated values of toxic units (∑TU) of Zn, Cu, Ni, Pb and Cr for all the sampling sites was lower than 4 and ranged from 6.01 to 9.26 with mean value of (8.02 ±1.09) for TRI, indicating a low toxic risk of the metals. The enrichment factor has the order of EFCo > EFMn >EFPb > EFCu >EFCr >EFZn >EFNi. According to the Igeo index classification, Fe, Zn, Ni and Cr may be practically unpolluted (Igeo ranged from -2.15 to -0.41) for the sediments study, while the Igeo of Co ranged from moderately to strongly polluted. According to the values of PLI (ranged from 1.25 to 1.67), the lake Edku was existed in polluted and moderately polluted
Keywords: Sediment, Heavy Metals, Lake Edku, Enrichment Factor
Full Text (.pdf)  International Journals Of Engineering and Science | 794 KB
Title: The Effect of Using 1.7 W of 940 nm Diode Laser on Radicular Dentin Permeability and Smear Layer Removal
Author(s): Ruaa M. Al-Mafrach, Lutfi G.Awazli, Mohammed A. Al-Maliky, Ruaa M. Al-Mafrachi
Pages: 24-27 Paper ID:182906-5757-IJBAS-IJENS Published: December, 2018
Abstract: Background: Near-infrared diode lasers can be used for several applications, which range from disinfection to smear layer removal in endodontics. This study aimed to evaluate the effect of using 1.7 W of 940 nm diode laser on root canal dentin permeability and removal of the smear layer. Method: twentyeight extracted human mandibular premolars teeth were instrumented up to X4 file of ProTaper next rotary system (Dentsply Maillefer, Ballagues, Switzerland) irrigated with 1 ml 5.25% NaOcl between files and then randomly divided into 2 groups (n = 14 for each group) control group and diode laser group. Afterward, the roots were coated with nail varnish to made them impermeable and then filled with 2%methylene blue dye, divided horizontally into three segments representing the apical, middle, and coronal thirds then examined under stereomicroscope. Using analytical software, the root section area and dye penetration area were measured, and then, the percentage of clear dye penetration area was calculated. Moreover, scanning electron microscope investigations were accomplished. The nonparametric Mann-Whitney U test was accomplished. Although the statistical analysis showed no significant difference between the two experimental groups over the three root thirds but the dye penetration in diode laser group was significantly higher over the whole root length compared to control group. Scanning electron micrographs of diode laser group showed a distinctive removal of smear layer with preservation of the annular structure of dentinal tubules, while control group produced uneven removal of smear layer, in efficient cleanliness especially in the apical third.
Keywords: Diode laser, Smear layer, Permeability, Root canal.
Full Text (.pdf)  International Journals Of Engineering and Science | 535 KB